Medical Xpress March 20, 2025
Researchers have uncovered a promising therapeutic target for adenoid cystic carcinoma (ACC), a rare cancer of the salivary glands with few treatment options.
The study, “PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands,” is published in the Journal of Experimental & Clinical Cancer Research.
The study, led by researchers from the University of Chicago Medicine Comprehensive Cancer Center, in collaboration with scientists from InSilico Medicine and Prelude Therapeutics, found that blocking the activity of protein arginine methyl transferase 5 (PRMT5) is a potential treatment strategy against ACC.
ACC accounts for only 1–5% of head and neck cancers and 25–35% of salivary gland neoplasms.
“The disease itself is very, very, very rare, which makes it...
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