Medical Xpress December 22, 2025
Craif Inc. in Nagoya, Japan, working with Nagoya University’s Institute of Innovation for Future Society, has developed a urine-based biological aging clock. In validation of the method, predicted ages came within 4.4 years of chronological age on average.
Aging, as we tend to understand it through chronological dating, is the primary driver behind many chronic diseases. But chronological age and biological age can differ, as some people age more rapidly or slower than others. Biomarker tools that can reliably estimate a patient’s biological age could support preventive health strategies.
Aging clocks estimate biological age from age-responsive features, and differences from chronological age can reflect the pace of aging. DNA methylation models pioneered aging clocks and found associations with morbidity and...
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