Medical Xpress November 1, 2021
The generation of chimeric RNAs had been identified as an exclusive feature of cancer cells, with chimeric RNAs being recognized as biomarkers and drug targets for different cancers. Recent studies, however, revealed the presence of chimeric RNAs in normal cells. At present, the functional and evolutionary significance of chimeric RNAs are not well understood. Researchers from the Azrieli Faculty of Medicine of Bar-Ilan University in Israel have now proposed a hypothesis to explain the evolutionary and functional significance of chimeric RNAs in human cells. According to this hypothesis, chimeric RNAs are important drivers of phenotypic diversity in human cells.
In a new paper published in the journal Trends in Genetics, Dr. Milana Frenkel-Morgenstern and her postdoctoral student Dr. Sumit Mukherjee...
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