Eric Topol October 11, 2025
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
If you’re interested in the science of healthspan and longevity, you’ve likely heard of the naked mole rat, a remarkable outlier among mammals that defies the laws of biologic aging. For nearly 30 years, we didn’t know what accounted for this phenomenon, but a compelling new report sheds light on a pathway that was only discovered in 2012, awarded the Lasker Prize in 2024, and is now the target of many clinical trials. This edition of Ground Truths is about the convergence of two exciting life science discoveries and how they may influence the future of medicine.
Background: Two Threads of Life Science Converge
By the late 1990s...
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