Forbes April 29, 2024
Despite the apparent success of Covid mRNA vaccines, fundamental issues remain. The limitations of the current Pfizer and Moderna vaccines include short lifetime, substantial cold chain requirements, and lack of mature B and T cell responses due to short-lived synthesized proteins. Two newly reported vaccines using a self-amplifying RNA technology may overcome these problems: GEMCOVAC-OM and ARCT-154. These two mRNA vaccines herald a new era of vaccination for coronaviruses. This article delves into the unique mechanisms of self-amplifying messenger RNA vaccines based on promising results from recent human trials.
Traditional mRNA vaccines contain a linear RNA instruction with pseudouridine modified nucleotides. When the mRNA enters your cells, they produce a protein that, if properly administered, induces an immune response.
Self-amplifying...
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