Medical Xpress August 19, 2025
Cerebrovascular diseases such as atherosclerosis and stroke remain a major cause of morbidity and mortality worldwide. A common feature of these diseases is vascular stenosis, i.e., the narrowing of blood vessels, which disrupts normal blood flow and contributes to chronic inflammation in the vessel wall. Endothelial cells lining the vasculature play a key role in sensing shear stress from blood flow and responding to disturbed hemodynamics by expressing pro-inflammatory molecules. However, studying this phenomenon in vivo is challenging due to the complexity and variability of living systems.
Traditional in vitro models, including static cultures and microfluidic devices, often fall short of replicating the structural, mechanical, and biological complexity of the human cerebrovascular environment. This emphasizes the need for a more...
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