The Brain and Long Covid

Eric Topol May 28, 2023

2 new studies shed light on persistent neuro-inflammation from even mild infections

Ever since the UK Biobank study that showed brain atrophy, loss of grey matter, and cognitive decline in about 400 people who had Covid compared with matched controls, via baseline (pre-Covid) and subsequent (~3 years later) MRI scans, there has been significant worry about the impact this virus has on the brain. Two new studies, both from researchers in Germany, illuminate the mechanisms for inflammation of brain tissue which is persistent and occurs even in patients with a mild Covid illness. Importantly, these were studies of people with Covid, not specifically individuals who were suffering from Long Covid.

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