Nature September 6, 2021
Mark McCarthy & Ewan Birney

To provide individual care and prevent disease, we need to go beyond genetics in risk scores and include metrics that follow a person’s changing environment and health.

Providing the best possible care for an individual means having a better understanding of their risks of developing disease. The goal is to have personalized answers when people need to know whether, for instance, preventive surgery makes sense, a given medicine is likely to be risky or a certain diet should be recommended.

Information on genetic risk represents one promising approach to providing these answers. Genomic data, gathered across millions of individuals, have revealed thousands of DNA sequence variants associated with common diseases such as diabetes, heart disease, schizophrenia and cancer. These clues...

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