STAT October 3, 2022
Jason Karlawish

The press release issued by pharmaceutical companies Eisai and Biogen on Sept. 27 might someday be remembered as the beginning of a revolution in Alzheimer’s diagnosis and treatment.

Years and years of failed Alzheimer’s trials created, and then fortified, doubts about whether drugs that attacked amyloid, a brain protein linked to Alzheimer’s disease, were a valid approach to its treatment. Those doubts may have been quelled.

The companies reported so-called top-line results of CLARITY-AD, a study of their drug lecanemab, among individuals with either mild cognitive impairment (MCI) or mild-stage dementia and evidence of accumulation of amyloid in their brain. “Top line” describes overall summaries of the results of the primary and secondary endpoints.

The drug slowed declines in both...

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