MedCity News November 30, 2021
Prescribers need a pharmacogenetics knowledge base to determine a safe and effective medication and dosage for their patients, but they also need pharmacogenetics test information to be easily accessible, interpretable and meaningful.
In the late 1990s and early 2000s, healthcare providers and researchers noticed that some patients with HIV (approximately 5%) experienced a severe hypersensitivity reaction to the drug abacavir, in some cases causing multiple organ failure, anaphylactic shock and even death. They were eager to determine why only certain patients were affected so they could continue to prescribe this highly effective therapy while minimizing the risk of potential harm. Early research urged providers to closely monitor patients taking abacavir and discontinue the therapy if signs of a reaction occurred.
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