Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

News-Medical.Net October 2, 2022
By Dr. Priyom Bose, Ph.D. Reviewed by Danielle Ellis, B.Sc.

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

Review Article: Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses. Image Credit: Huen Structure Bio / Shutterstock

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In the past few decades, several pathogenic human coronaviruses (HCoV) have emerged that have caused epidemics and a pandemic worldwide. Severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, and SARS-CoV-2 in 2019,...

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